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AE621 - SCLEROSE LATERALE AMYOTROPHIQUE

= MALADIE DE CHARCOT; ALS; SLA; Motor neuron disease; Amyotrophic lateral sclerosis

Thèmes > A - SYSTEME NEUROMUSCULAIRE > AE - MOELLE > AE6 - MALADIES DEGENERATIVES / MOELLE > AE62 - AMYOTROPHIE SPINALE PROGRESSIVE > AE621 - SCLEROSE LATERALE AMYOTROPHIQUE

Definition MESH: Degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts.

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