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The changes in human spinal sympathetic preganglionic neurons after spinal cord injury
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KRASSIOUKOV AV; BUNGE RP; PUCKET WR
SPINAL CORD , 1999, vol. 37, n° 1, p. 6-13 Doc n°: 89612 Localisation : Centre de Réadaptation de Lay St Christophe , en ligne Descripteurs : AE21 - ORIGINE TRAUMATIQUE Url : http://www.nature.com/sc/archive/index.html We have applied conventional histochemical, immunocytochemical and morphometric techniques to study the changes within the human spinal sympathetic preganglionic neurons (SPNs) after spinal cord injury. SPNs are localized within the intermediolateral nucleus (IML) of the lateral horn at the thoraco-lumbar level of the spinal cord and are the major contributors to central cardiovascular control. SPNs in different thoracic segments in the normal spinal cord were similar in soma size. SPNs in the IML were also identified using immunoreactivity to choline acetyltransferase. Soma area of SPNs was 400.7+15 microm2 and 409.9+/-22 microm2 at the upper thoracic (T3) and middle thoracic (T7) segments, respectively. In the spinal cord obtained from a person who survived for 2 weeks following a spinal cord injury at T5, we found a significant decrease in soma area of the SPNs in the segments below the site of injury: soma area of SPNs at T8 was 272.9+/-11 microm2. At T1 the soma area was 418+/-19 microm2. In the spinal cord obtained from a person who survived 23 years after cord injury at T3, the soma area of SPNs above (T1) and below (T7) the site of injury was similar (416.2+/-19 and 425.0+/-20 microm2 respectively). The findings demonstrate that the SPNs in spinal segments caudal to the level of the lesion undergo a significant decrease of their size 2 weeks after spinal cord injury resulting in complete transection of the spinal cord. The impaired cardiovascular control after spinal cord injury may be accounted for, in part, Langue : ANGLAIS Identifiant basis : 1999205418 |
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