Article

The authors' two studies using cDNA microarrays to profile the transcriptome pattern in response to endurance and resistance exercise have shed new light on exercise-mediated adaptation in skeletal muscle. Given that the two modes of exercise that the authors used represented the "extremes" of the exercise continuum, most forms of therapeutic exercise likely fall somewhere between them. One potential value of the data would be to provide transcriptome "signatures" that could be used to screen a variety of interventions that may enhance the pattern, including nutritional, pharmacologic, or alternative exercise paradigms. The data also could be used as a standard by which to compare the exercise response from a variety of patient populations to identify which components of the response could be altered by the disease in question. Future work is needed to map out the timeline of the response and to determine whether specific transcriptome patterns lead to idiosyncratic proteomic and phenotypic responses after a period of exercise training.

Langue : ANGLAIS