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Conducting multiple-site clinical trials in medical rehabilitation research
FUHRER M
AM J PHYS MED REHABIL , 2005, vol. 84, n° 11, p. 823-831 Doc n°: 122250 Localisation : Documentation IRR Descripteurs : HD - ORGANISATION DE LA REEDUCATION - READAPTATION This article examines the distinctive opportunities and challenges of multiple-site clinical trials, as distinguished from trials conducted by a single program. Among the topics discussed are: the role of clinical trials generally in medical rehabilitation research; definitions of ''clinical trials'' and ''multiple site''; the distinction between exploratory and capstone trials; the potential advantages and disadvantages of multiple-site trials; planning issues in terms of sampling designs, the choice of outcome measures, approaches to dealing with intervention fidelity, organizational structures, authorship, and the conduct of collateral studies; and implementation issues in terms of pilot-testing procedures, handling emerging issues, and optimizing communication. Langue : ANGLAIS |
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