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Formes tardives de myasthénie - Etude comparative avec la myasthénie du sujet jeune
BARBAUD A; CARLANDER B
REV NEUROL (Paris) , 2006, vol. 162, n° 10, p. 990-996 Doc n°: 126097 Localisation : Documentation IRR Descripteurs : AB12 - PATHOLOGIE / ETUDES GENERALES / MUSCLES, MA - GERONTOLOGIE, AD35 - DYSPHAGIE The incidence of myasthenia gravis appears to be increasing in elderly but few studies have been devoted to late onset myasthenia gravis. METHODS: We retrospectively compared myasthenic patients with an age at onset above or below 35 years which were observed in two departments of Neurology from 1980 to 2002. RESULTS: 81 cases were included, 28 of which were late onset myasthenia gravis. The two populations were similar in terms of sex-ratio, clinical symptoms, course of the disease and therapeutic response. There was a trend for older patients to present more frequently at onset with dysphagia and axial or proximal involvement, and to have extra-ocular symptoms more quickly. Antibodies against acetylcholine receptor and striated muscle were statistically more frequent in elder patients. CONCLUSIONS: A late onset is not a factor of poor prognosis in myasthenia gravis and older patients must be treated in the same way than younger ones. Langue : FRANCAIS |
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