Article

Toxine botulique et hyperactivité détrusorienne réfractaire non-neurogène
PURPOSE: To study the value and efficacy of botulinum toxin for treatment of
cases of non-neurogenic detrusor overactivity (NNDO) that are refractory to
anticholinergic drugs. METHODS: A systematic review of the
literature, based on a keyword search of the Medline database. Selection of
articles in French and English (meta-analyses, reviews, case studies and
randomized, controlled clinical trials) on intradetrusor botulinum toxin
injection in the management of refractory NNDO. RESULTS: Nineteen publications
(including three randomized, controlled trials) were selected. Intradetrusor
injection of botulinum toxin in patients with refractory NNDO has produced
promising results, with a significant improvement in physical symptoms,
urodynamic parameters and quality of life. The rare side effects consist
primarily of dose-dependent urine retention. CONCLUSION: On the basis of
preliminary data, botulinum toxin appears to be a valuable therapeutic option and
fills the gap between anticholinergics and surgery in the treatment of NNDO that
is refractory to anticholinergic agents. Botulinum toxin has a promising future
in urology but requires further scientific evaluation.

Langue : ANGLAIS