Article

The aim of the study was to determine which vasoactive agent was more efficacious
for erectile dysfunction (ED), intracavernosal papaverine or oral sildenafil, in
paraplegic men within the first year after injury by using a penile color Doppler
ultrasound as a quantitative imaging method and to determine the association
between responses to these two vasoactive agents and factors such as neurological
lesion level and lesion severity. A total of 31 male in-patients with spinal cord
injury, aged over 18 years, and with neurological lesions below the T6 level
within the first year after injury with ED were included. Visual and auditory
sexual stimulus (VASS) on day 1 (group 1), VASS with 25 mg intracavernosal
papaverine (group 2) and after a wash-out period of papaverine on day 2, and VASS
with 50 mg oral sildenafil on day 5 (group 3) were administered to each patient.
Measurements of the peak systolic velocity and end diastolic velocity, which were
used as vascular parameters during each procedure type, were taken using penile
color Doppler ultrasound. Considering the severity of the lesion and the levels
of the neurological lesion, there was a statistically significant difference
between the PSV values of the group 1 and the other two groups (P<0.05). There
was no statistically significant difference between the peak systolic velocity
and end diastolic velocity values of groups 2 and 3 (P>0.05) in terms of both the
severity and the levels of the lesion. Efficacies of intracavernosal papaverine
hydrochloride or oral sildenafil citrate for ED were similar at all neurological
lesion levels and lesion severity in paraplegic men within the first year after
spinal cord injury.

Langue : ANGLAIS