Article

New micro-vessels formation within synovium and macro-vessels endothelial damage
with atheroma are two major features of rheumatoid arthritis,
the former related
to the articular involvement of the disease, the latter to its main systemic
complication. The similarities between pannus development and solid tumors
growth, and the efficacy of anti-angiogenic treatments in oncology, opened the
perspective of directly targeting angiogenesis in arthritis. Nevertheless,
despite the success of different anti-angiogenic therapeutic strategies in many
arthritis experimental models, the application in human disease is still lacking.
Recent data suggest that synovial neoangiogenesis and macro-vessels endothelial
damage might be two linked phenomena. While synovial angiogenesis seems to be
detrimental to endothelial damage repair, even anti-angiogenic treatments might
paradoxically aggravate macro-vascular disease, especially in the context of
uncontrolled inflammation. These elements induce to further explore the interconnections between inflammation and angiogenesis on one side and between
micro- and macro-vascular diseases on the other, in order to establish the proper
way to therapeutically target blood vessels in rheumatoid arthritis.
CI - Copyright (c) 2010 Societe francaise de rhumatologie. Published by Elsevier SAS.
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Langue : ANGLAIS