Article

Body mass index, a measure of relative weight, is increasingly
recognized as an important risk factor for osteoarthritis, especially in weight bearing joints.
The objective was to assess the association between body mass
index and hip osteoarthritis susceptibility and investigate the difference
between sex, study type and osteoarthritis definition. METHODS: We did electronic
searches of Medline, Embase and Cochrane library from the commencement to
December 2009. A meta-analysis and meta-regression was executed to quantitatively
assess the strength of associations between body mass index and hip
osteoarthritis risk. Study-specific incremental estimates were standardized to
determine the risk associated with a 5 kg/m(2) increase in body mass index.
RESULTS: Fourteen epidemiological studies were included. Our study showed that
body mass index was significantly positive associated with hip osteoarthritis
risk. A 5-unit increase in body mass index was related to an increased risk of
hip osteoarthritis (RR: 1.11; 95%CI: 1.07, 1.16). The magnitudes of associations
were similar in women as compared with men (women, RR: 1.10; 95%CI: 1.05, 1.15;
men, RR: 1.08; 95%CI: 1.04, 1.12; p > 0.05). The summary estimates were 1.12
(95%CI: 1.02, 1.24) in case-control studies and 1.11 (95%CI: 1.06, 1.16) in
cohort studies (p > 0.05). Body mass index was positively associated with hip
osteoarthritis defined by radiography and/or clinical symptom (RR: 1.04; 95%CI:
1.00, 1.07) and clinical surgery (RR: 1.16; 95%CI: 1.11, 1.22) with no
significant difference (p > 0.05). CONCLUSION: Increased body mass index
contributes to a positive effect on susceptibility to hip osteoarthritis.
Associations between body mass index and hip osteoarthritis risk do not vary by
sex, study design or osteoarthritis definition.
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Langue : ANGLAIS