Article

From Baron Dupuytren's historical description up to the advent of molecular
biology, many hypotheses about the etiology of Dupuytren's disease have been
proposed. This bibliography of the last ten years' publications describes tissue
anomalies from the macroscopic down to the ultrastructural level of pathology.
The myofibroblast, which is the principal cell of the disease, is the seat of
genetics anomalies involving proto-oncogenes (c-myc and MafB). Similarly,
glycoproteins implicated in cellular adhesion like fibronectins and catenins are
modified and overexpressed in the disease.
Extracellular proteins of the
metalloproteinase family exhibit many dysfunctions responsible for collagenic
proliferation. Finally, growth factors like Transforming Growth Factor (TGF) and
Epidermal Growth Factor (EGF) receptor maintain and worsen the disease and could
be therapeutic targets in the future.
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Langue : FRANCAIS