Article

We previously demonstrated that stimulating neuronal nicotinic acetylcholine
receptors modulates prospective memory (PM), the ability to remember and
implement a prior intention. Here we used fMRI to explore the neuronal correlates
of acute nicotinic (1mg) modulation during PM, employing a double blind,
valence-matched placebo-controlled design, and a solely event-related analysis.
Eight healthy adults completed on two occasions (1 week washout) a simple
attentional task containing infrequent PM trials. PM activated bilateral
parietal, prefrontal (BA10) and anterior cingulate, and deactivated genual
cingulate and medial prefrontal regions. Further, acute nicotine administration
decreased activity within a largely overlapping right parietal region. This data
validates a purely event-related approach to exploring PM, and suggests
procholinergic modulation of PM by parietal rather than BA10/frontal regions.
CI - Crown Copyright (c) 2011. Published by Elsevier Ltd. All rights reserved.

Langue : ANGLAIS