Article

AIM: To examine the relation of axial and appendicular bone properties in
ambulatory children with cerebral palsy (CP) to functional
(Gross Motor Function
Classification System [GMFCS]) level. METHOD: Quantitative computed tomography
measurements were compared among 37 children with CP (12 children in GMFCS level
I, five in level II, 18 in level III, two in level IV; five with hemiplegia, 23 with diplegia, two with triplegia, seven with quadriplegia; mean age 9y 4mo, SD
1y 6mo; 18 males, 19 females) and 37 children in a comparison group (same age and
sex distributions). Linear regression was used to evaluate differences in
volumetric cancellous bone density (vBMD) and geometric properties of the L3
vertebra and tibia, adjusting for height, weight, and sex as covariates. RESULTS:
The comparison group had larger vertebrae than the children with CP (p = 0.02)
owing to smaller vertebral size in GMFCS levels III and IV, but there was no
difference in vertebral vBMD (p = 0.49). In the tibia, bone volumetric density (p
= 0.09) and size (p = 0.02) decreased with increasing GMFCS level. GMFCS level
had a greater effect on bone size in females than in males (p<0.07).
INTERPRETATION: Children with CP of all levels may have less bone in their
tibias, whereas spine deficits differentially affect more involved children.
Because even small bone deficits may manifest as osteoporosis later in life, it
is important to study bone acquisition in all children with CP.
CI - (c) The Authors. Journal compilation (c) Mac Keith Press 2010.
- Fractures

Langue : ANGLAIS