Article

The use of functional MRI (fMRI) in combination with pharmacological challenges
has increased exponentially in recent years, motivated by the idea not only to
elucidate the neurochemical foundations of human emotional and cognitive
faculties, but also to optimize human brain function in healthy individuals and
identify novel drug targets, with the ultimate goal to design more specific
pharmacological therapies for the various disorders of human emotion and
cognition. In particular, emotional responding of the amygdala has become a
central interest, and pharmacological fMRI has been used to specifically probe,
and modulate, amygdala activation in response to facial expressions of emotion
and emotionally laden scenes. This article reviews recent fMRI experiments
manipulating the amygdala's physiological response to such stimuli by
pharmacological means and lays a particular focus on monoaminergic,
glutamatergic, GABAergic, and hormonal/peptidergic challenges.
CI - Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Langue : ANGLAIS