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Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus : effects on gait in Parkinson's disease

PEPPE A; PIERANTOZZI M; CHIAVALON C; MARCHETTI F; CALTAGIRONE C; MUSICCO M; STANZIONE P; STEFANI P
GAIT POSTURE , 2010, vol. 32, n° 4, p. 512-518
Doc n°: 152501
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1016/j.gaitpost.2010.07.012
Descripteurs : AF5 - PARKINSON, DF23 - PATHOLOGIE - MARCHE

This study examines the effects of subthalamic nucleus (STN) deep
brain stimulation (DBS) and pedunculopontine tegmentum (PPTg) DBS in advanced
Parkinson's disease using gait analysis. METHODS: Five people underwent bilateral
DBS in both the STN and PPTg. Gait analysis was performed one year after
neurosurgery using an optoelectronic system. The effects of DBS (STN, PPTg and
STN+PPTg) were studied in two clinical conditions: without (Off) and during (On)
antiparkinsonian therapy. RESULTS: PPTg and STN DBS were associated with changes
in spatio-temporal and kinematics variables. CONCLUSIONS: Although experimental
data cannot be generalized widely due to the small sample, PPTg DBS appears to
affect the neuronal circuits subserving gait.
CI - Copyright (c) 2010 Elsevier B.V. All rights reserved.

Langue : ANGLAIS

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