Article

This meta-analysis provides a systematic review of studies into intellectual
and attentional functioning of paediatric brain tumour survivors (PBTS) as
assessed by two widely used measures: the Wechsler Intelligence Scale for
Children (3rd edition; WISC-III) and the Conners' Continuous Performance Test
(CPT). METHOD: Studies were located that reported on performance of PBTS (age
range 6-16y). Meta-analytic effect sizes were calculated for Full-scale IQ,
Performance IQ, and Verbal IQ as measured by the WISC-III, and mean hit reaction
time, errors of omission, and errors of commission as measured by the CPT.
Exploratory analyses investigated the possible impacts of treatment mode, tumour
location, age at diagnosis, and time since diagnosis on intelligence. RESULTS:
Twenty-nine studies were included: 22 reported on the WISC-III in 710 PBTS and
seven on CPT results in 372 PBTS. PBTS performed below average (p(s) <0.001) on
Full-scale IQ (Cohen's d=-0.79), Performance IQ (d=-0.90), and Verbal IQ
(d=-0.54). PBTS committed more errors of omission than the norm (d=0.82,
p<0.001); no differences were found for mean hit reaction time and errors of
commission. Cranial radiotherapy, chemotherapy, and longer time since diagnosis
were associated with lower WISC-III scores (p(s) <0.05). INTERPRETATION: PBTS
have seriously impaired intellectual functioning and attentiveness. Being treated
with cranial radiotherapy and/or chemotherapy as well as longer time since
diagnosis leads to worse intellectual functioning.
CI - (c) The Authors. Developmental Medicine & Child Neurology (c) 2012 Mac Keith
Press.

Langue : ANGLAIS