Article

Systematic reviewObjectives:Review the use of generic
preference-based measures of health-related quality of life (HRQoL) within the
context of spinal cord injury (SCI).Methods:A systematic search was conducted to
identify SCI-related publications that contained any of the following
preference-based HRQoL instruments: 15D, Assessment of Quality of Life (AQoL)-4D,
AQoL-6D, EQ-5D, EQ-5D-5L, Health Utilities Index (HUI)-2, HUI-3, Quality of
Well-Being Scale Self-Administered (QWB-SA), SF-6D(SF-36) or SF-6D(SF-12). In
addition to providing an overview of how different preference-based measures have
been adopted in SCI research to-date, a focus of evaluation was to collate and
appraise evidence for measurement properties and identify knowledge
gaps.Results:Twenty-two articles were identified. No studies have used
preference-based measures in their conventional form, that is, to calculate
quality-adjusted life years using patient-level data. Eleven papers reported mean
utility scores (across six different instruments). Directly comparable data
exists for only one SCI-specific sample, which showed variation across EQ-5D
(0.63), HUI-2 (0.81) and HUI-3 (0.68) index scores. Indirect comparisons
suggested differences between QWB-SA and SF-6D index scores within tetraplegic
and paraplegic patient groups. Only the QWB-SA and SF-6D have undergone (partial)
psychometric evaluation, with the respective authors concluding that the measures
have potential for SCI research.Conclusions:Despite 'cost-effectiveness' being an
increasingly important consideration for decision makers in all areas of health
care, there is a distinct lack of conceptual or empirical research regarding the
appropriateness of alternative preference-based HRQoL measures for SCI
populations. Given the support for economic evaluation within a cost-utility
framework and the paucity of psychometric evidence regarding current instruments,
further research is needed.

Langue : ANGLAIS