Article

The major objectives of this cross-sectional study were to (1) measure
insulin-like growth factor-1 (IGF-1) in individuals with complete spinal cord
injury (SCI) and spasticity and (2) determine the relationships between IGF-1 and
cross-sectional areas (CSAs) of thigh skeletal muscle groups. Eight individuals
with motor complete SCI underwent magnetic resonance imaging to measure the CSA
of the whole thigh, knee extensor, and knee flexor skeletal muscle groups and
dual-emission X-ray absorptiometry to measure fat-free mass. After participants
fasted for 12 h, we measured their IGF-1 levels and determined spasticity using
the Modified Ashworth Scale (MAS). Spearman rho correlations were used to test
for the relationships among the tested variables, and independent t-tests were
used to determine the difference in plasma IGF-1. Plasma IGF-1 was 44% greater in
those with MAS scores of 2 or higher (p < 0.05). Plasma IGF-1 was positively
related to knee extensor skeletal muscle CSA (r = 0. 83, p < 0.01). IGF-1 was
strongly related to knee extensor and flexor spasticity (r = 0.88, p < 0.004).
The findings suggest that IGF-1 is greater in SCI individuals with increased
spasticity, and this may explain the strong positive relationships that were
noted between spasticity and skeletal muscle CSA.

Langue : ANGLAIS