Article

AIM: To analyse factors associated with fractures in children with cerebral palsy
(CP) in different levels of Gross Motor Function Classification System (GMFCS).
METHOD: This was an epidemiological retrospective study of a total population of
536 children (214 females, 322 males) with CP born between 1990 and 2005. CP type
was unilateral spastic (n=159), bilateral spastic (n=225), ataxic (n=60),
dyskinetic (n=80), and mixed type (n=12); 384 children were in Gross Motor
Function Classification Scale (GMFCS) levels I-III and 152 children were in GMFCS
levels IV-V. Data were collected for a 9-year period on sex, CP-type, GMFCS
level, gastrostomy, height, weight, the use of a standing device, antiepileptic
drug (AED) therapy, and fractures. RESULTS: The risk of fracture in the total
population of children with CP was similar to that for typically developing
children. The risk for fractures of those in GMFCS levels I-III was not
significantly associated with any of the studied risk factors. The risk of
fractures for those in GMFCS levels IV-V on AED therapy was a twofold increase
(p=0.004). The risk for fractures without trauma in children with stunted growth
(height for age <-3 SD) and those who did not use standing devices was
significantly increased: adjusted incidence rate ratio (AIRR) 4.16 (p=0.011) and
3.66 (p=0.010) respectively. Results regarding gastrostomy feeding for those in
GMFCS levels IV-V were conflicting: a gastrostomy was associated with a reduced
risk of fractures with trauma, but with increased risk of fractures without
trauma (AIRR 0.10, p=0.003 and 4.36, p=0.012) respectively. INTERPRETATION:
Children in GMFCS levels I-III had a similar incidence and pattern for fractures
as normally developing children. Those in GMFCS levels IV-V had stunted growth,
often a sign of longstanding undernourishment, and were associated with an
increased risk of fractures. Children using standing devices had a fourfold
reduction of fractures without trauma. Regular loading exercises and early
adequate nutritional intake could prevent fractures in severe CP.
CI - (c) 2013 Mac Keith Press.

Langue : ANGLAIS