Article

Falls are a significant issue in people with multiple sclerosis (MS),
with research demonstrating fall rates of more than 50%.
The purpose of
this study was to evaluate the risk factors associated with falling in people with MS. DATA SOURCES: Mixed search methods were used, including computer-based
and manual searches. Additionally, hand searches of reference lists and
conference abstracts were performed. All literature published from the source's
earliest date to January 2012 was included; only full-text English-language
sources (or those where a translation was available) were included. STUDY
SELECTION: Eligibility criteria specified articles evaluating any aspect of fall
risk in adults with a confirmed MS diagnosis, where the incidence of falling as
determined by prospective or retrospective participant report was included. DATA
EXTRACTION: Data were extracted independently by 2 reviewers using a written
protocol and standardized extraction documentation. Detailed assessment of each
article was independently undertaken by both reviewers, including assessment of
study quality using an adaptation of the Newcastle Ottawa Scale plus extraction
of key data (participant characteristics, fall incidence, and outcomes). DATA
SYNTHESIS: The final review comprised 8 articles with a total of 1,929
participants; 1,037 (53.75%) were classified as fallers. Eighteen different risk
factors were assessed within the included studies. Meta-analysis demonstrated an
increase in fall risk associated with impairments of balance and cognition,
progressive MS, and use of a mobility aid. Narrative review of the qualitative
articles and those factors where meta-analysis was not possible also was
undertaken. LIMITATIONS: Variation in assessment, analysis, and reporting methods
allowed meta-analysis for only 4 factors. CONCLUSION: There is limited evidence
of the factors associated with fall risk in people with MS. Further
methodologically robust studies are needed.

Langue : ANGLAIS