Article

OBJECTIVE: To investigate the impact of high-frequency chest wall oscillation in
chronic obstructive pulmonary disease patients with infective exacerbation.
DESIGN: Clinical randomized controlled trial. SETTING: Patients received
high-frequency chest wall oscillation therapy at the Department of Pulmonology.
SUBJECTS: Stage III-IV chronic obstructive pulmonary disease patients
hospitalized with acute infective exacerbation who had received high-frequency
chest wall oscillation therapy were studied. INTERVENTIONS: Patients were
randomized into two groups, which were classified as I and II. All patients have
been treated with bronchodilators, antibiotics, if necessary oxygen and patient
education, as part of acute chronic obstructive pulmonary disease exacerbation
protocol. Group II patients received additional high-frequency chest wall
oscillation therapy. MAIN MEASURES: Body mass index (B), forced expiratory volume
in the first second (O), modified Medical Research Council dyspnea scale (D) and
6-minute walking test (E) (BODE) index, forced expiratory volume in the first
second, dyspnea, exercise capacity, oxygenation parameters and hospitalization of
duration were recorded at baseline and at three-days and five-days follow-up.
RESULTS: From April 2009 to July 2011, a total of 99 patients were assessed for
eligibility, 50 patients were enrolled and randomized into two groups. A total of
50 (100%) patients (25 in Group I and 25 in Group II) were followed up for five
days. Application of high-frequency chest wall oscillation therapy resulted in no
significant advantage in all outcomes (p > 0.05). Mean (SD) baseline BODE index
value in Group I was 7.72 (1.76), in Group II was 7.72(1.89)
(p = 0.55). On the
fifth-day assessment, mean (SD) BODE index value in Group I was 7.24 (1.83), in
group II was 6.44 (2.46) (p = 0.18). CONCLUSIONS:
The application of
high-frequency chest wall oscillation therapy offers no additional advantages on
infective exacerbations in chronic obstructive pulmonary disease.

Langue : ANGLAIS