Article

Many diffusion tensor imaging (DTI) studies have reported an
association between cingulum injury and cognition in patients with traumatic
brain injury (TBI) using DTI parameters. In this study, we attempted to
investigate the relation between cingulum injury and cognition in chronic
patients with TBI, using the integrity of the cingulum as well as DTI parameters.
METHOD: Thirty five consecutive chronic patients with TBI were recruited. The
intelligence quotient (IQ) of the Wechsler Intelligence Scale and Memory
Assessment Scale (MAS) was used for assessment of cognition. The patients were
classified into three groups, according to continuity to the lower portion of the
genu of the corpus callosum: type A-both sides of the cingulum showed intact
continuity, type B-either cingulum showed a discontinuation, and, type C-both
cingulums showed discontinuation. We measured the fractional anisotropy (FA),
apparent diffusion coefficient (ADC), and voxel number of both cingulums.
RESULTS: The IQ and MAS scores of type A and B were significantly higher than
those of type C, respectively (p < 0.05), however, we did not observe a
significant difference between type A and type B (p > 0.05). A positive
correlation was observed between the FA value of the cingulum, and IQ and MAS,
respectively (IQ r = 0.373, p < 0.05, MAS r = 0.357, p < 0.05), and between the
voxel number and MAS (r = 0.500, p < 0.05). By contrast, we observed a negative
correlation between the ADC value and IQ (r = -0.353, p < 0.05). CONCLUSION: In
terms of integrity to the basal forebrain and DTI parameters of the injured
cingulum, DTI findings showed a close association with whole cognition and memory
in chronic patients with TBI.

Langue : ANGLAIS