Article

Epidémiologie -
The objective of this study was to assess the prevalence and incidence
of multiple sclerosis (MS) in the Lorraine region, in France. METHODS: Data from
three sources - Regional Health Insurance System, medical records departments and
the Lorraine registry of MS - and a capture-recapture method with log-linear
models were used to estimate the prevalence and incidence of MS. RESULTS: We
identified 7193 records of reported MS corresponding to 4299 unique suspected
cases of MS existing on 31 December 2008, in Lorraine. On the basis of the 4001
validated cases, the observed crude prevalence of MS was 170.9 cases per 100,000
inhabitants (95% confidence interval [CI]: 165.7; 176.3), and the observed annual
crude incidence of MS was 4.4 cases per 100,000 inhabitants (95% CI: 3.6; 5.4).
With the capture-recapture method, the estimated prevalence of MS was 4405.7 (95% CI: 4261.5; 4629.7), so an estimated 405 cases were not identified by the three
sources. The estimated prevalence was 188.2 cases per 100,000 inhabitants (95%
CI: 182.7; 193.8), and the estimated annual incidence was 8.5 cases per 100,000
inhabitants (95% CI: 7.3; 9.7). CONCLUSIONS: The capture-recapture method allowed
us to estimate an additional 10.1% of unobserved prevalent cases and to
anticipate 47.5% of unobserved incident cases.

Langue : ANGLAIS

Tiré à part : OUI