Article

Mitochondrial dysfunction has been reported in most neurodegenerative diseases.
These anomalies include bioenergetic defect, respiratory chain-induced oxidative
stress, defects of mitochondrial dynamics, increase sensitivity to apoptosis, and
accumulation of damaged mitochondria with instable mitochondrial DNA. Significant
progress has been made in our understanding of the pathophysiology of inherited
mitochondrial disorders but most have no effective therapies. The development of
new metabolic treatments will be useful not only for rare mitochondrial disorders
but also for the wide spectrum of common age-related neurodegenerative diseases
shown to be associated with mitochondrial dysfunction. A better understanding of
the mitochondrial regulating pathways raised several promising perspectives of
neuroprotection. This review focuses on the pharmacological approaches to
modulate mitochondrial biogenesis, the removal of damaged mitochondria through
mitophagy, scavenging free radicals and also dietary measures such as ketogenic
diet.
CI - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS