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Hypothermia as a clinical neuroprotectant

SHERMAN AL; WANG MY
PHYS MED REHABIL CLIN N AM , 2014, vol. 25, n° 3, p. 519-529
Doc n°: 170231
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1016/j.pmr.2014.04.003
Descripteurs : AE21 - ORIGINE TRAUMATIQUE

Applying therapeutic hypothermia (TH) for the purposes of neuroprotection,
originally termed "hibernation," started nearly 100 years ago. Because TH cooling
systems have improved to the point where it is practical and safe for general
application, interest in providing such treatment in conditions such as spinal
cord injury, traumatic brain injury, stroke, and cardiac arrest has increased.
This article reviews the mechanisms by which TH mitigates secondary neurologic
injury, the clinical scenarios where TH is being applied, and reviews selected
published studies using TH for central nervous system neuroprotection.
CI - Copyright (c) 2014 Elsevier Inc. All rights reserved.

Langue : ANGLAIS

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