Article

The NeuroFlexor objectively quantifies the neural, elastic and viscous
components of passive movement resistance in wrist and finger flexor muscles. In
this study we investigated the sensitivity of the NeuroFlexor to changes in
spasticity induced by treatment with botulinum toxin type A (BoNT-A). Design:
Prospective observational design. Subjects: A convenience sample of 22 adults
with post-stroke upper limb spasticity scheduled for botulinum toxin treatment.
Methods: BoNT-A was given according to individual treatment plans. NeuroFlexor
assessments were made before treatment and 4 and 12 weeks after. Results: At group level, spasticity decreased significantly at 4 weeks (expected time of
maximum effect) (p = 0.04). At 12 weeks, spasticity had rebounded and no longer
differed significantly from baseline (p = 0.64), i.e. in line with the
pharmacodynamics of BoNT-A. At the individual level, 7 participants showed a
reduction in spasticity greater than the measurement error. The reduction was
dose-dependent (r(20) = 0.66, p < 0.001), and largest in participants with the
highest dose. Conclusion:
At the group level, the sensitivity of NeuroFlexor is
good enough to detect reduction in spasticity after treatment with BoNT-A.
Further work is needed to establish the sensitivity of NeuroFlexor on an
individual level.

Langue : ANGLAIS