Article

OBJECTIVE: To determine whether there is an association between improvements in
objective measures of physical fitness and performance on cognitive tests in
people with multiple sclerosis (MS). DESIGN: Post hoc correlational analysis in
which people demonstrating physical improvement were compared with those not
demonstrating physical improvement. SETTING: Individuals with MS residing in the
community. PARTICIPANTS: Adults with clinically confirmed MS (N=88) who
participated in a controlled trial of a telephone-based health promotion
intervention, chose to work on exercise, and completed the pre- and
postintervention assessments. INTERVENTIONS: Participants were measured for
strength (isokinetic dynamometer), aerobic fitness (bicycle ergometer), and
cognition (Paced Auditory Serial Addition Test [PASAT], Trail Making Test [TMT])
at baseline and 12 weeks later. Change in fitness was calculated by subtracting
each participant's baseline score from the outcome score, and then transforming
the difference to a z score. Individuals with a z score >/=1 on any fitness
measure were placed in the physically improved group (n=25). All others were in
the physically not improved group (n=57). MAIN OUTCOME MEASURES TMT, PASAT
RESULTS: After controlling for covariates (age, sex, ethnicity, education,
disease activity, MS type), there was a significant group-by-time interaction,
suggesting that cognitive functioning changed over time based on level of
fitness. Participants in the physically improved group demonstrated improved
performance on measures of executive functioning after 12 weeks of exercise.
CONCLUSIONS: The results of this study lend support to the hypothesis that change
in fitness is associated with improved executive functioning in people with MS.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS