Article

The aim of the study was to evaluate patient-specific determinants of
responsiveness to robot-enhanced repetitive treadmill therapy (ROBERT) in
patients with early-developed movement disorders.
METHOD: Patients were treated
over 12 sessions during a 3-week period. Gross Motor Function Measure-66
(GMFM-66) scores 1 day before ROBERT were compared with scores recorded 1 day
after ROBERT. The association of GMFM-66 baseline score, age, sex, aetiology, and
add-on botulinum toxin therapy to response to treatment was assessed. RESULTS:
Eighty-three patients aged between 4 and 18 years (48 males, 35 females; mean age
10y 8mo, SD 6y 1mo; Gross Motor Function Classification System level I [n=12], II
[n=21], III [n=35], IV [n=10], and V [n=1]) were each treated for a total of 7.2
(SD 1.9) treadmill walking hours. Aetiology was bilateral spastic cerebral palsy
(BS-CP; n=69), unilateral CP (n=3), ataxic CP (n=3), hereditary spastic
paraparesis (n=6), and genetic syndrome including spasticity (n=2). Meaningful
improvements were observed in GMFM-66 (+2.5; 95% CI 2.0-3.0), GMFM-D (+5.2; 95%
CI 3.6-6.8), and GMFM-E (+4.0; 95% CI 2.8-5.3). There was a high inter-individual
variability in treatment response. After multivariable adjustment, the
improvements in GMFM-66 and GMFM-E scores were positively associated with the
GMFM-66 baseline score. The effect on GMFM-D improvement was inversely associated
with age. INTERPRETATION: Gross motor abilities at baseline and age were
identified as relevant determinants for the high degree of interpersonal
variability in response to ROBERT.
CI - (c) 2014 Mac Keith Press.

Langue : ANGLAIS