Article

Despite suffering from poor prognosis, progressive exercise
intolerance, and impaired quality of life (QoL), effective therapeutic strategies
in heart failure with preserved ejection fraction (HFpEF) are sparse. Exercise
training (ET) improves physical QoL in HFpEF, but the effects on other aspects of
QoL are unknown. METHODS:
The multicentre, prospective, randomized, controlled
Exercise training in Diastolic Heart Failure Pilot study included 64 HFpEF
patients (65 +/- 7 years, 56% female). They were randomized to supervised
endurance/resistance training in addition to usual care (ET, n = 44) or usual
care alone (UC, n = 20). At baseline and after 3 months, QoL was assessed
(36-item Short-form Health Survey (SF-36), Minnesota Living With Heart Failure
Questionnaire (MLWHFQ), and Patient Health Questionnaire (PHQ-9). RESULTS:
Exercise improved the following SF-36 dimensions: physical functioning (p <
0.001, p = 0.001 vs. UC), bodily pain (p = 0.046), general health perception (p <
0.001, p = 0.016 vs. UC), general mental health (p = 0.002), vitality (p =
0.003), social functioning (p < 0.001) physical (p < 0.001, p = 0.001 vs. UC),
and mental component score (p = 0.030). ET did not improve role limitations due
to physical and emotional problems. The MLWHFQ total scale (p < 0.001) and the
MLWHFQ physical limitation scale (p < 0.001, p = 0.04 vs. UC) also improved with
ET. The MLWHFQ emotional limitation scale did not change with ET. With ET, also
the PHQ-9 total score improved significantly (p = 0.004, p = 0.735 vs. UC).
CONCLUSIONS: In patients with HFpEF, exercise training improved emotional status,
physical and social dimensions of QoL as well as symptoms of depression from pre
to post test. Physical dimensions of QoL and general health perception also
improved significantly with exercise in comparison to usual care.
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Langue : ANGLAIS