Article

Clinical research has consistently detected alteration in central pain processing
leading to hypersensitivity. Most methods used in humans are reliable and have
face validity to detect widespread central hypersensitivity. However, construct
validity is difficult to investigate due to lack of gold standards. Reference
values in the pain-free population have been generated, but need replication.
Research on pain biomarkers that reflect specific central hypersensitivity
processes is warranted. Few studies have analyzed the prognostic value of central
hypersensitivity. Most medications acting at central level and some
non-pharmacological approaches, including psychological interventions, are likely
to attenuate central hypersensitivity.
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Langue : ANGLAIS