Article

OBJECTIVES: To investigate whether functionally based resistance exercise could
improve strength, physical function, and disability among prostate cancer
survivors (PCS) on androgen deprivation therapy (ADT); and to explore potential
mediators of changes in outcomes from exercise.
DESIGN: Randomized controlled
trial. SETTING: Academic medical center. PARTICIPANTS: PCS (N=51; mean age,
70.2y) on ADT. INTERVENTION: PCS were randomized to moderate to vigorous
intensity resistance training or stretching (placebo control) for 1 year. MAIN
OUTCOME MEASURES: Maximal leg press and bench press strength, objective and
self-reported physical function, and self-reported disability. Hierarchical
linear modeling was used to test for significant group x time differences
adjusting for covariates. RESULTS: Retention in the study was 84%, and median
attendance to supervised classes was 84% in the resistance group. No
study-related injuries occurred. Maximal leg strength (P=.032) and bench press
strength (P=.027) were improved after 1 year of resistance training, whereas
little change occurred from stretching. Self-reported physical function improved
with resistance training, whereas decreases occurred from stretching (P=.016).
Disability lessened more with resistance training than stretching (P=.018).
One-year change in leg press strength mediated the relation between groups
(resistance or stretching) and 1-year change in self-reported disability (P<.05).
CONCLUSIONS: One year of resistance training improved muscle strength in
androgen-deprived PCS. Strengthening muscles using functional movement patterns
may be an important feature of exercise programs designed to improve perceptions
of physical function and disability. Findings from this study contribute to the
mounting evidence that exercise should become a routine part of clinical care in
older men with advanced prostate cancer.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS