Article

OBJECTIVE: To evaluate the effect of long-term physical activity (PA) and acute
exercise on markers of systemic inflammation in persons with chronic spinal cord
injury (SCI). DATA SOURCES: We searched PubMed (MEDLINE), EMBASE, Central
Register of Controlled Trials, CINAHL, and PEDro, involving variations of the
Medical Subject Headings: SCI, PA, exercise, and inflammation. No time or
language restrictions were applied. STUDY SELECTION: Except for case reports, we
included any type of study, both sexes, all ages, with SCI, resulting in the
inclusion of 11 studies. PA included leisure or work activity, including
exercise. DATA EXTRACTION: Two authors independently scanned titles and abstracts
and read the articles included. One author extracted and the second
double-checked the data. The methodological quality and evidence were rated by
using the Cochrane Risk of Bias tool or the Newcastle-Ottawa Scale and the
Grading of Recommendations Assessment, Development and Evaluation approach. DATA
SYNTHESIS: The included studies had a high risk of bias and "very low" levels of
evidence. Meta-analyses were performed (random-effects model or generic inverse
variance method). The acute interleukin-6 (IL-6) response to exercise was the
same for individuals with SCI and able-bodied individuals (P=.91); however,
responses were higher in those with paraplegia than in those with tetraplegia
(weighted mean difference, 1.19, P<.0001, and 0.25, P=.003, respectively).
Compared with physically inactive people with SCI, physically active people with
SCI had lower plasma C-reactive protein (CRP) levels (weighted mean difference,
-0.38; P=.009). CRP concentrations were lower after the exercise intervention
than before the exercise intervention (weighted mean difference, -2.76; P=.0001).
CONCLUSIONS: PA and exercise may improve systemic markers of low-grade
inflammation in those with SCI, particularly IL-6 and CRP. The change in IL-6 and
CRP levels seems to be greater in those with paraplegia than in those with
tetraplegia.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS