Article

The aim of this study was to explore the most relevant determinants
of severe disability in a heterogeneous sample of patients with neurological
conditions. OBJECTIVES: We used data from previous studies on patients with
myasthenia gravis (MG), migraine, Parkinson's disease (PD), multiple sclerosis,
traumatic brain injury (TBI), stroke and epilepsy (349 patients, aged 18-74
years; mean 48.0, SD 11.7). We calculated count-based extension indexes to
address severe disability, and hierarchical logistic regression to assess the
association between severe disability, sociodemographic and health status
information. CONCLUSIONS: Results show that sociodemographic variables played a
minor role, while health state information was a stronger determinant of severe
disability. Compared to the reference value of TBI patients, those with MG, PD
and epilepsy had higher odds to have severe difficulties undertaking daily
activities despite the presence of environmental factors. Our results contrast
with those of previous studies, mostly derived from general populations, showing
the different impact of clinical and sociodemographic variables.

Langue : ANGLAIS