Article

Air pollution (indoors and outdoors) is a major issue in public health as
epidemiological studies have highlighted its numerous detrimental health
consequences (notably, respiratory and cardiovascular pathological conditions).
Over the past 15years, air pollution has also been considered a potent
environmental risk factor for neurological diseases and neuropathology. This review examines the impact of air pollution on children's brain development and
the clinical, cognitive, brain structural and metabolic consequences. Long-term
potential consequences for adults' brains and the effects on multiple sclerosis
(MS) are also discussed. One challenge is to assess the effects of lifetime
exposures to outdoor and indoor environmental pollutants, including occupational
exposures: how much, for how long and what type. Diffuse neuroinflammation,
damage to the neurovascular unit, and the production of autoantibodies to neural
and tight-junction proteins are worrisome findings in children chronically
exposed to concentrations above the current standards for ozone and fine
particulate matter (PM2.5), and may constitute significant risk factors for the
development of Alzheimer's disease later in life. Finally, data supporting the
role of air pollution as a risk factor for MS are reviewed, focusing on the
effects of PM10 and nitrogen oxides.
CI - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS