Article

OBJECTIVES: To examine differences in adipose tissue distribution, lumbar
vertebral bone mineral density (BMD), and muscle attenuation in adults with and
without cerebral palsy (CP),
and to determine the associations between
morphologic characteristics. DESIGN: Cross-sectional, retrospective analyses of
archived computed tomography scans. SETTING:
Clinical treatment and
rehabilitation center. PARTICIPANTS: Adults (N=352) with CP (age, 38.8+/-14.4y;
body mass, 61.3+/-17.1kg; Gross Motor Function Classification System levels, I-V)
and a matched cohort of neurotypical adults. Of the 41 adults with CP included in
the study, 10 were not matchable because of low body masses. INTERVENTIONS: Not
applicable. MAIN OUTCOME MEASURES: Computed tomography scans were assessed for
visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas, psoas
major area and attenuation in Hounsfield units (Hu), and cortical and trabecular
BMDs. RESULTS: Adults with CP had lower cortical (beta=-63.41 Hu, P<.001) and
trabecular (beta=-42.24 Hu, P<.001) BMDs and psoas major areas
(beta=-374.51mm(2), P<.001) and attenuation (beta=-9.21 Hu, P<.001) after
controlling for age, sex, and body mass. Adults with CP had greater VAT
(beta=3914.81mm(2), P<.001) and SAT (beta=4615.68mm(2), P<.001). Muscle
attenuation was significantly correlated with trabecular (r=.51, P=.002) and
cortical (r=.46, P<.01) BMD, whereas VAT was negatively associated with cortical
BMD (beta=-.037 Hu/cm(2), r(2)=.13, P=.03). CONCLUSIONS: Adults with CP had lower
BMDs, smaller psoas major area, greater intermuscular adipose tissue, and greater
trunk adiposity than neurotypical adults. VAT and cortical BMD were inversely
associated.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS