Article

Radiologically isolated syndrome (RIS) is a new subtype entity
described at the very left of the demyelinating disease spectrum, where spatial
dissemination of T2-weighted lesions can be documented on MRI in subjects with no
history of neurological symptoms. OBJECTIVES:
This study was a longitudinal
assessment of health-related quality of life (HRQOL) and fatigue in RIS patients.
METHODS: Non-converted RIS patients were evaluated at the time of diagnosis, and
at 1 and 2 years of follow-up; their scores were compared with scores in
clinically isolated syndrome (CIS) patients and age-matched controls. RESULTS:
Sociodemographic characteristics were comparable at baseline. There was no
statistical difference between RIS and CIS groups in terms of cerebrospinal fluid
(CSF) positivity or T2 lesion load. For HRQOL evaluations, RIS patients scored
the same as controls, while CIS patients scored lower. Fatigue was detectable in
both RIS and CIS patients compared with baseline and with controls. Mental HRQOL
scores decreased significantly for RIS patients during follow-up. CONCLUSION:
HRQOL impairment and fatigue were detectable during follow-up in both
non-converted RIS and CIS patients.
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Langue : ANGLAIS