Article

There is a large literature reporting risk factor analyses for poor
neurodevelopment in children born very preterm (VPT: </=32wks) or very low
birthweight (VLBW: </=1250g), which to date has not been formally summarized. The
aim of this paper was to identify prognostic factors for cerebral palsy (CP) and
motor impairment in children born VPT/VLBW. METHOD: A systematic review was
conducted using Medline, Embase, and Pyscinfo databases to identify studies
published between 1 January 1990 and 1 June 2014 reporting multivariable
prediction models for poor neurodevelopment in VPT/VLBW children (registration
number CRD42014006943). Twenty-eight studies for motor outcomes were identified.
RESULTS: There was strong evidence that intraventricular haemorrhage and
periventricular leukomalacia, and some evidence that the use of postnatal
steroids and non-use of antenatal steroids, were prognostic factors for CP. Male
sex and gestational age were of limited use as prognostic factors for CP in
cohorts restricted to </=32 weeks gestation; however, in children older than 5
years with no major disability, there was evidence that male sex was a predictive
factor for motor impairment.
This review has identified factors
which may be of prognostic value for CP and motor impairment in VPT/VLBW children
and will help to form the basis of future prognostic research.
CI - (c) 2016 Mac Keith Press.

Langue : ANGLAIS