Article

Tremor is a highly prevalent movement disorder that markedly reduces quality of
life. The management of severe tremor is particularly challenging.
Pharmacological treatment is available, but no real breakthrough has emerged
recently. Propranolol and primidone are still the two most recommended agents,
followed by topiramate. However, surgical treatments for medically refractory
tremors are expanding. Gamma knife (GK) thalamotomy is an option particularly
suitable for patients who are not candidates for deep brain stimulation. Owing to
the fact that it is a non-invasive procedure without craniotomy, GK radiosurgery
has almost no contraindications. Since the late 1990s, more than 250 case reports
and patient series have been published. Most of these studies show that
unilateral GK thalamotomy is well tolerated and reduces tremor disability. A
recent study with prospective blinded assessment has confirmed its safety,
together with significant improvements in tremor scores and activities of daily
living.
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Langue : ANGLAIS