Article

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are two
atypical parkinsonian syndromes first described half a century ago. The spectrum
of these conditions as well as, more generally, the concept of tauopathy have
dramatically changed over the past decade and especially in recent years. In
particular, clinicopathological correlations have led to the description of
several subtypes of these diseases and the features they share with other
neurodegenerative diseases. The present paper is a review of how the concepts of
PSP and CBD have evolved over time. In particular, it focuses on the different
presentations of the disease and the overlapping syndromes that can complicate
the differential diagnoses. Also discussed are some of the tools that may prove
useful in making a diagnosis. Indeed, differential diagnosis issues are of
particular importance in light of the likely emergence of pathology-specific
disease-modifying therapies in the near future.
CI - Copyright (c) 2016 Elsevier Masson SAS. All rights reserved.
- Tauopathies

Langue : ANGLAIS