Article

OBJECTIVE: To investigate the relation between fractional anisotropy (FA), a
suggested biomarker for tissue integrity, and motor recovery in patients with
stroke after postacute rehabilitation. DESIGN: Retrospective study. SETTING:
Acute rehabilitation hospital. PARTICIPANTS: Subjects (N=43) diagnosed with
ischemic stroke (n=28) and hemorrhagic stroke (n=15).
The average age for
subjects was 68+/-14 years. INTERVENTIONS: Magnetic resonance imaging and
diffusion tensor imaging were conducted on all patients.
MAIN OUTCOME MEASURES:
The admission and discharge motor subscores of the FIM were obtained from medical
records, and relative gain was calculated using the Montebello Rehabilitation
Factor Score (MRFS). K-means cluster analysis (K=3) using both the MRFS and the
gain of the FIM motor subscore (DeltaFIM) was performed. Analysis of variance was
used to determine the difference in FA among the clusters. Spearman analysis was
conducted to examine the relation between FA, DeltaFIM, and MRFS in each cluster.
RESULTS: FA was significantly higher in the clusters of good and moderate
recovery in the corticospinal tract (CST), peduncle, and posterior limb of the
internal capsule bilaterally (all P<.05) compared with the poor recovery group.
Significant positive correlations were observed in multiple regions along the CST
between FA, DeltaFIM, and MRFS in the clusters of good and moderate recovery, but
not in the poor recovery group. CONCLUSIONS: Our results showed an association
between FA values within the corticospinal tract and motor recovery in patients
with stroke undergoing postacute rehabilitation.
This finding may help to
identify novel targets for new interventions to promote stroke recovery.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS