Article

OBJECTIVE: To identify changes in concentrations of inflammatory mediators in
plasma and urine after traumatic spinal cord injury (SCI) and before the
occurrence of a first pressure ulcer. DESIGN: Retrospective; secondary analysis
of existing data. SETTING:
Acute hospitalization and inpatient rehabilitation
sites at a university medical center. PARTICIPANTS: Individuals with a pressure
ulcer and plasma samples
(n=17) and individuals with a pressure ulcer and urine
samples (n=15) were matched by age and plasma/urine sample days to individuals
with SCI and no pressure ulcer (N=35). INTERVENTIONS: Not applicable. MAIN
OUTCOME MEASURES: Plasma and urine samples were assayed in patients with SCI,
capturing samples within 4 days after the SCI to a week before the formation of
the first pressure ulcer. The Wilcoxon signed-rank test was performed to identify
changes in the inflammatory mediators between the 2 time points. RESULTS: An
increase in concentration of the chemokine interferon-gamma-induced protein of
10kd/CXCL10 in plasma (P<.01) and a decrease in concentration of the cytokine
interferon-alpha in urine (P=.01) were observed before occurrence of a first
pressure ulcer ( approximately 4d) compared with matched controls. CONCLUSIONS:
Altered levels of inflammatory mediators in plasma and urine may be associated
with pressure ulcer development after traumatic SCI. These inflammatory mediators
should be explored as possible biomarkers for identifying individuals at risk for
pressure ulcer formation.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS