Article

Genetic variations in the dopamine (DA) system are associated with
cortical-striatal behavior in multiple populations.
This study assessed
associations of functional polymorphisms in the ankyrin repeat and kinase domain
(ANKK1; Taq1a) and catechol-O-methyltransferase (COMT; Val158Met) genes with
behavioral dysfunction following traumatic brain injury (TBI). PARTICIPANTS: This
was a prospective study of 90 survivors of severe TBI recruited from a level 1
trauma center. MAIN MEASURES: The Frontal Systems Behavior Scale, a self- or
family report questionnaire evaluating behavior associated with frontal lobe
dysfunction, was completed 6 and 12 months postinjury. Depression was measured
concurrently with the Patient Health Questionnaire-9. Study participants were
genotyped for Val158Met and Taq1a polymorphisms. RESULTS: No statistically
significant behavioral differences were observed by Taq1a or Val158Met genotype
alone. At 12 months, among those with depression, Met homozygotes (Val158Met)
self-reported worse behavior than Val carriers (P = .015), and A2 homozygotes
(Taq1a) self-reported worse behavior than A1 carriers (P = .028) in bivariable
analysis. Multivariable models suggest an interaction between depression and
genetic variation with behavior at 12 months post-TBI, and descriptive analysis
suggests that carriage of both risk alleles may contribute to worse behavioral
performance than carriage of either risk allele alone. CONCLUSION: In the context
of depression, Val158Met and Taq1a polymorphisms are individually associated with
behavioral dysfunction 12 months following severe TBI, with preliminary evidence
suggesting cumulative, or perhaps epistatic, effects of COMT and ANKK1 on
behavioral dysfunction.
CI - (c) The Author(s) 2016.

Langue : ANGLAIS