Article

Insulin-like growth factor-1 (IGF-1) is neuroprotective after stroke
and is regulated by insulin-like binding protein-3 (IGFBP-3).
In healthy
individuals, exercise and improved aerobic fitness (peak oxygen uptake; peak VO2)
increases IGF-1 in circulation. Understanding the relationship between estimated
prestroke aerobic fitness and IGF-1 and IGFBP-3 after stroke may provide insight
into the benefits of exercise and aerobic fitness on stroke recovery. Objective
The purpose of this study was to determine the relationship of IGF-1 and IGFBP-3
to estimated prestroke peak VO2 in individuals with acute stroke. We hypothesized
that (1) estimated prestroke peak VO2 would be related to IGF-1 and IGFBP-3 and
(2) individuals with higher than median IGF-1 levels will have higher estimated
prestroke peak VO2 compared to those with lower than median levels. Methods
Fifteen individuals with acute stroke had blood sampled within 72 hours of
hospital admission. Prestroke peak VO2 was estimated using a nonexercise
prediction equation. IGF-1 and IGFBP-3 levels were quantified using enzyme-linked
immunoassay. Results Estimated prestroke peak VO2 was significantly related to
circulating IGF-1 levels (r = .60; P = .02) but not IGFBP-3. Individuals with
higher than median IGF-1 (117.9 ng/mL) had significantly better estimated aerobic
fitness (32.4 +/- 6.9 mL kg-1 min-1) than those with lower than median IGF-1
(20.7 +/- 7.8 mL kg-1 min-1; P = .03). Conclusions Improving aerobic fitness
prior to stroke may be beneficial by increasing baseline IGF-1 levels. These
results set the groundwork for future clinical trials to determine whether high
IGF-1 and aerobic fitness are beneficial to stroke recovery by providing
neuroprotection and improving function.
CI - (c) The Author(s) 2016.

Langue : ANGLAIS