Article

Complex regional pain syndrome type I (CRPS I) is a multifactorial painful
disorder with a complex pathogenesis. Both peripheral and central mechanisms are
involved. Acute CRPS I is considered to be an exaggerated inflammatory disorder;
however, over time, because of altered function of the sympathetic nervous system
and maladaptive neuroplasticity, CRPS I evolves into a neurological disorder.
This review thoroughly describes the pathophysiological aspects of CRPS I and
summarizes the potential therapeutic options. The mechanisms and targets of the
treatment are different in the early and late stages of the disease. This current
review builds on a previous review by this author group by deepening the role of
the peripheral classic and neuronal inflammatory component in the acute stage of
this painful disorder.
LEVEL OF EVIDENCE: Not applicable.
CI - Copyright (c) 2017 American Academy of Physical Medicine and Rehabilitation.
Published by Elsevier Inc. All rights reserved.

Langue : ANGLAIS