Article

OBJECTIVES: To determine (1) whether the serum concentration of 25-hydroxy
vitamin D (25(OH)D3) was associated with depression levels in people with chronic
spinal cord injury (SCI) and
(2) whether any observed association was independent
of potential confounders. DESIGN: Cross-sectional study. SETTING: Rehabilitation
institute. PARTICIPANTS: Patients with chronic SCI (N=100) recruited consecutively. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Patients
underwent clinical and biochemical evaluations, including assessment of 25(OH)D3
levels and the presence and severity of depressive symptoms, by using the
interviewer-assisted self-report Beck Depression Inventory-II (BDI-II). RESULTS:
Depression (BDI-II score >/=14) was observed in 15 of 28 women (53.6%) and 18 of
72 men (25.0%) of the study population. They exhibited significantly lower
25(OH)D3 levels, lower functional independence degree in performing activities of
daily living, poorer engagement in leisure time physical activity, and higher
body mass index. Lower 25(OH)D3 levels were associated with higher BDI-II scores
as well as with the occurrence of depression. These associations persisted after
adjustment for all significant predictors of the BDI-II score that were selected,
as possible confounders, by univariate analysis. In receiver operating
characteristic analysis, a 25(OH)D3 level of <9.99ng/mL had the highest accuracy
in discriminating patients with depression. CONCLUSIONS: In people with chronic
SCI, an inverse association exists between serum 25(OH)D3 levels and depressive
symptoms, widely independent of potential confounders, especially those, peculiar
to this population, that can mediate the effects of depression on vitamin D levels.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS