Article

The repertoire of measures of walking in Rett syndrome is limited.
This study aimed to determine measurement properties of a modified two-minute
walk test (2MWT) and a modified Rett syndrome-specific functional mobility scale
(FMS-RS) in Rett syndrome. METHODS: Forty-two girls and women with Rett syndrome
(median 18.4 years, range 2.4-60.9 years) were assessed for clinical severity,
gross motor skills, and mobility. To measure walking capacity, 27 of this group
completed a 2MWT twice on two different assessment days. To assess walking
performance, the FMS-RS was administered to the total sample of parents (n = 42)
on two occasions approximately one week apart. RESULTS: There were negative
correlations between clinical severity and 2MWT (r = -0.48) and FMS-RS (r =
-0.60-0.66). There were positive correlations between gross motor skills and
mobility and 2MWT (r = 0.51, 0.43) and FMS-RS (r = 0.71-0.93, 0.74-0.94),
respectively. Test-retest reliability for the 2MWT was good with high intraday
and interday correlations (ICC = 0.86-0.98). For the 2MWT, the standard error of
measurement was 13.8 m and we would be 95% confident that changes greater than 38
m would be greater than within subject error. There was good test-retest
reliability for all three distances on the FMS-RS (ICC = 0.94-0.99). CONCLUSIONS:
Walking capacity as measured by the 2MWT showed expected but limited
relationships with measures of different constructs, providing some support for
concurrent validity. Walking performance as measured with the FMS-RS was more
strongly consistent with other clinical measures supporting its concurrent
validity. Test-retest reliability was good for both the FMS-RS and the 2MWT.
Therefore, these measures have the potential to be used in clinical practice and
research. Implications for Rehabilitation Walking is one of the commonest daily
physical activities in ambulant girls and women with RTT. Comprehensive knowledge
about the walking abilities in this population is limited. Evidence of validity
and test-retest reliability have been demonstrated for the modified two-minute
walk test (2MWT) and the Rett syndrome-specific functional mobility scale
(FMS-RS). The 2MWT and FMS-RS offer detailed information of the capacity and
performance of walking, respectively, in girls and women with RTT.
- Encéphalopathie

Langue : ANGLAIS