Article

Memory complaints and deficits are common in patients with epilepsy, especially
temporal lobe epilepsy (TLE), where memory-related brain structures are directly
involved in the epileptic process. In recent years, substantial progress has been
made in delineating memory impairment in TLE, challenging the traditional
neuropsychological approach of the disorder. In particular, several lines of
evidence have suggested that, beyond the apparent deficit demonstrable by
standardized neuropsychological evaluations, TLE may also negatively interact
with long-term memory, producing considerable loss of information of the
patient's autobiographical history and an inability to maintain newly acquired
information over a period of time. These observations have led to the development
of innovative assessment techniques, and prompted a new domain of investigation
focused on the relationships between interictal epileptiform activities and the
integrity of anatomo-functional systems. The present paper reviews the available
evidence for long-term memory deficits in TLE with respect to remote and very
long-term memory, and discusses their putative pathophysiological mechanisms and
the developing potential strategies to improve memory functioning.
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Langue : ANGLAIS