Article

No studies comparing the effects of platelet-rich plasma (PRP)
injection and placebo injection in bilateral knee osteoarthritis in the same
patient, or discussing muscle strength after PRP injection,
have been published.
DESIGN: Twenty patients with bilateral knee osteoarthritis were eligible, and 40
knees were randomized into two groups: PRP (knees [right or left by a coin toss]
receiving a single intra-articular PRP injection) and saline group (the
contralateral knee of the same patient, into which single 4-mL intra-articular
injection of normal saline was administered). The primary outcome measure was
Western Ontario and McMaster's Universities Osteoarthritis Index and the
secondary included isokinetic test results. The evaluation was at baseline and at
2 wks, 1, 3, and 6 mos after injection. RESULTS: The PRP group showed a
significant reduction in the Western Ontario and McMaster's Universities
Osteoarthritis Index pain and total scores compared with normal saline group (P <
0.05). Although a significantly greater percentage of knee strength (extensor >
flexor) was found in the PRP group during a longer follow-up period, PRP
treatment resulted in insignificant differences in muscle strength compared with
normal saline. CONCLUSIONS: Platelet-rich plasma treatment significantly improves
pain, stiffness, and disability in patients with knee osteoarthritis compared
with normal saline treatment. Additional strength training is recommended to
enhance muscle strength recovery.

Langue : ANGLAIS