Article

The high prevalence of chronic pain in individuals with cerebral palsy (CP)
across the lifespan has been well documented, as has its negative impact on
quality of life. However, without an understanding of the underlying (possibly
unique) pathophysiology of pain in CP, identification of more effective
management options, such as innovative and individualized pharmacological
approaches to non-opioid pain treatment, will be significantly hindered. We
review, briefly, what is known about chronic pain in CP and present what we need
to know with respect to the neurobiology of pain and new developments in pain
treatment research that might be applied to CP. WHAT THIS PAPER ADDS: Pain
conditions in cerebral palsy have differing mechanisms and will not respond to
the same treatments. Novel analgesics under development include inhibitors of ion
channels, nerve growth factor, and calcitonin gene-related peptide.
CI - (c) 2018 Mac Keith Press.

Langue : ANGLAIS