RééDOC
75 Boulevard Lobau
F 54042 NANCY cedex

Accueil
03 83 52 67 61
Documentalistes
03 83 52 67 64

HORAIRES
0

Article

--";3! O
     

-A +A

Increased Single-Fiber Jitter Level Is Associated With Reduction in Motor Function With Aging

CHUNG T; TIAN Y; WALSTON J; HOKE A
AM J PHYS MED REHABIL , 2018, vol. 97, n° 8, p. 551-556
Doc n°: 188603
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1097/PHM.0000000000000915
Descripteurs : AD3 - MOTRICITE, MA - GERONTOLOGIE

Age-associated skeletal muscle weakness is a major contributing factor
to an increased late life mortality and morbidity, but its neurobiology is poorly
understood. Previously, we provided histological evidence of dying-back axonal
degeneration of motor neurons and denervation of neuromuscular junctions in
age-associated muscle weakness. Given this, we aimed to evaluate the relation
between impaired neuromuscular transmission and various aspects of age-associated
muscle weakness.
DESIGN: We compared two electrophysiological measures,
single-fiber jitter and compound motor action potential in mice of different age
groups, and correlated them with various physical performance measures, such as
grip strength, standing and walking time, and treadmill performance. RESULTS:
Consistent with our previous histological data, single-fiber jitter, a measure of
neuromuscular junction transmission, was significantly increased in older
animals, whereas compound motor action potential shows no difference between
young and old age groups. Neither jitter nor compound motor action potential
correlated with any of physical performance measures, except for jitter and
standing activity. CONCLUSIONS: Impaired neuromuscular transmission-represented
as increase in single-fiber electromyography jitter level-reflects decline in
motor function with aging.

Langue : ANGLAIS

Mes paniers

4

Gerer mes paniers

0
0