Article

Neuropathic pain is difficult to treat. Recommended first-line treatments include
tricyclic antidepressants and alpha2delta agonists pregabalin and gabapentin for
multiple neuropathic conditions, the antidepressants duloxetine and venlafaxine
in diabetic painful neuropathies and lidocaine patches for postherapetic
neuralgia. Therapeutic prospects include focal therapy with sustained analgesic
efficacy (capsaicin patches, botulinum toxin), treatments acting on new targets
(i.e., cytokine inhibitors, metabotropic glutamate inhibitors, TRPV1
antagonists). The methodology of clinical trials also tends to take better into
account the symptomatic profiles of patients, which should contribute to better
prediction or responders to treatment.
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Langue : FRANCAIS